* Eagle Eye Golf
* Echo Night: Beyond
* Ed, Edd n Eddy: The Mis-Edventures
* Energy Airforce (Taito) - UK: SLES52310
* Energy Airforce Aim Strike! (Taito) - UK: SLES52265
* Enter the Matrix (Shiny Entertainment)
* Enthusia Professional Racing (Konami) - UK: SLES53125
* Ephemeral Fantasia (Konami)
* Eragon
* Escape from Monkey Island
* Ethan Nelson's Adventure through Time and Space (E-Tech)
* ESPN College Hoops
* ESPN Major League Baseball
* ESPN National Hockey Night
* ESPN NBA 2K5
* ESPN NBA Basketball
* ESPN NFL 2K5
* ESPN NFL Football
* ESPN NHL 2K5
* ESPN NHL Hockey
* ESPN X Games Skateboarding (Konami) - UK: SLES50430
* Eternal Quest
* Eternal Ring
* EOE: Eve of Extinction
* Everblue
* Everblue 2
* Evergrace
* EverQuest Online Adventures
* EverQuest Online Adventures: Frontiers
* Everybody S Tennis
* Evil Dead: A Fistful of Boomstick
* Evil Dead: Regeneration
* Evil Twin
* Extermination
* Extreme-G 3
* EyeToy: AntiGrav (Sony)
* EyeToy: Chat (Sony)
* EyeToy: Groove (Sony)
* EyeToy: Kinetic
* EyeToy: Monkey Mania
* EyeToy: Operation Spy
* EyeToy: Play (Sony)
* EyeToy: Play 2 (Sony)
* EyeToy: Play 3
